Dimethylformamide → 3-Chloro-4-iodo-N,N-dimethylbenzenesulfonamide

HRID 1694743

Reaktionsgleichung

Reaktionsgleichung von HRID 1694743
[H-].[Na+].[Cl:3][C:4]1[CH:5]=[C:6]([S:11](N)(=[O:13])=[O:12])[CH:7]=[CH:8][C:9]=1[I:10].CI.[CH3:17][N:18]([CH:20]=O)C>>[Cl:3][C:4]1[CH:5]=[C:6]([S:11]([N:18]([CH3:20])[CH3:17])(=[O:12])=[O:13])[CH:7]=[CH:8][C:9]=1[I:10]

Komponenten

5

Edukt 4

HCID 6228DimethylformamideHCID 6328Methyl iodideHCID 24758Sodium hydrideHCID 672810493-Chloro-4-iodobenzenesulfonamide

Produkt 1

HCID 672802043-Chloro-4-iodo-N,N-dimethylbenzenesulfonamide

Versuchsvorschrift

Sodium hydride (0.33 g) was added to a solution of the product from step (i) (1.2 g) in DMF (25 ml) and stirred for 20 min. Methyl iodide (0.5 ml) was added dropwise and then stirred for a further 1 h. The reaction mixture was quenched with water, extracted with EtOAc, dried (MgSO4) and evaporated. The residue was treated with ether to give to give the subtitle compound as a white solid. Yield 0.45 g.

Aufarbeitung

  1. stirringstirred for a further 1 h
  2. customThe reaction mixture was quenched with water
  3. extractionextracted with EtOAc
  4. dry with materialdried (MgSO4)
  5. customevaporated
  6. additionThe residue was treated with ether
  7. customto give

Quellen und Nachweise

ORD-Eintrag
ord-8e940acfa8d143c38dcbfcb1a59be9ad
Quelldatensatz
uspto-grants-2012_04
Patentnummer
US08158820B2

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