(2S)-2-(2-borono-4-chlorophenoxy)-propanoic acid → 2-[4-Chloro-2-[4-methyl-6-[methyl(methylsulfonyl)amino]-3-pyridinyl]phenoxy]-(2s)-propanoic acid

HRID 1694763

Reaktionsgleichung

Reaktionsgleichung von HRID 1694763
Br[C:2]1[C:3]([CH3:14])=[CH:4][C:5]([N:8]([CH3:13])[S:9]([CH3:12])(=[O:11])=[O:10])=[N:6][CH:7]=1.B([C:18]1[CH:29]=[C:28]([Cl:30])[CH:27]=[CH:26][C:19]=1[O:20][C@@H:21]([CH3:25])[C:22]([OH:24])=[O:23])(O)O>>[Cl:30][C:28]1[CH:27]=[CH:26][C:19]([O:20][C@@H:21]([CH3:25])[C:22]([OH:24])=[O:23])=[C:18]([C:2]2[CH:7]=[N:6][C:5]([N:8]([CH3:13])[S:9]([CH3:12])(=[O:11])=[O:10])=[CH:4][C:3]=2[CH3:14])[CH:29]=1

Komponenten

3

Edukt 2

HCID 67277298(2S)-2-(2-borono-4-chlorophenoxy)-propanoic acidHCID 67280607N-(5-Bromo-4-methyl-2-pyridinyl)-N-methylmethanesulfonamide

Produkt 1

HCID 583336512-[4-Chloro-2-[4-methyl-6-[methyl(methylsulfonyl)amino]-3-pyridinyl]phenoxy]-(2s)-propanoic acid

Versuchsvorschrift

The title compound was prepared by the method of example 155 using the product from step (ii) and the product from example 151 step (iv). Yield 0.125 g.

Quellen und Nachweise

ORD-Eintrag
ord-28c6aaf17ecc4e7ead3f0558f57bb518
Quelldatensatz
uspto-grants-2012_04
Patentnummer
US08158820B2

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