Methylamine → 4-(2-Amino-8-(3-(n-(+)-biotinyl-6-aminocaproyl)-aminopropyl)-9h-purin-6-yloxymethyl)-benzyl-amine

HRID 1695095

Reaktionsgleichung

Reaktionsgleichung von HRID 1695095
[NH2:1][C:2]1[N:10]=[C:9]2[C:5]([N:6]=[C:7]([CH2:11][CH2:12][CH:13]([NH2:37])[C:14](=[O:36])[CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][NH:20][C:21](=[O:35])[CH2:22][CH2:23][CH2:24][CH2:25][C@H:26]3[C@@H:34]4[C@@H:29]([NH:30][C:31]([NH:33]4)=[O:32])[CH2:28][S:27]3)[NH:8]2)=[C:4]([O:38][CH2:39][C:40]2[CH:53]=[CH:52][C:43]([CH2:44][NH:45]C(=O)C(F)(F)F)=[CH:42][CH:41]=2)[N:3]=1.CN>CO>[NH2:1][C:2]1[N:10]=[C:9]2[C:5]([N:6]=[C:7]([CH2:11][CH2:12][CH:13]([NH2:37])[C:14](=[O:36])[CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][NH:20][C:21](=[O:35])[CH2:22][CH2:23][CH2:24][CH2:25][C@H:26]3[C@@H:34]4[C@@H:29]([NH:30][C:31]([NH:33]4)=[O:32])[CH2:28][S:27]3)[NH:8]2)=[C:4]([O:38][CH2:39][C:40]2[CH:41]=[CH:42][C:43]([CH2:44][NH2:45])=[CH:52][CH:53]=2)[N:3]=1

Komponenten

4

Edukt 2

HCID 6329MethylamineHCID 178508950HCID 178508950, Verbindung

Produkt 1

HCID 1785098634-(2-Amino-8-(3-(n-(+)-biotinyl-6-aminocaproyl)-aminopropyl)-9h-purin-6-yloxymethyl)-benzyl-amine

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

Trifluoroacetamide 49 (Example 32, 15.1 mg, 0.019 mmol) are dissolved in 1 mL methanol, and 2 mL methylamine (33% in ethanol) are added. The reaction mixture is stirred at room temperature for 48 h and all volatiles are removed in vacuo. The product is used without further purification. MS (ESI) m/z 667.5 [M+H]+.

Aufarbeitung

  1. customall volatiles are removed in vacuo
  2. customThe product is used without further purification

Quellen und Nachweise

ORD-Eintrag
ord-6a442575b20c422eaabb803b44b96fad
Quelldatensatz
uspto-grants-2012_04
Patentnummer
US08163479B2

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