1,1-Dimethylethyl [[3',5-dichloro-4'-(methylsulfinyl)[1,1'-biphenyl]-2-yl]oxy]acetate → HCID 67277260, Verbindung

HRID 1695120Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1695120
[Cl:1][C:2]1[CH:3]=[C:4]([C:11]2[CH:16]=[C:15]([Cl:17])[CH:14]=[CH:13][C:12]=2[O:18][CH2:19][C:20]([O:22]C(C)(C)C)=[O:21])[CH:5]=[CH:6][C:7]=1[S:8]([CH3:10])=[O:9]>C(O)(C(F)(F)F)=O>[Cl:1][C:2]1[CH:3]=[C:4]([C:11]2[CH:16]=[C:15]([Cl:17])[CH:14]=[CH:13][C:12]=2[O:18][CH2:19][C:20]([OH:22])=[O:21])[CH:5]=[CH:6][C:7]=1[S:8]([CH3:10])=[O:9]

Komponenten

3

Edukt 1

HCID 866203721,1-Dimethylethyl [[3',5-dichloro-4'-(methylsulfinyl)[1,1'-biphenyl]-2-yl]oxy]acetate

Produkt 1

HCID 67277260HCID 67277260, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6422Trifluoroacetic acidLösungsmittel

Versuchsvorschrift

A solution of the more polar product from Example 2 step d) (35 mg) in TFA (2 ml) was stirred for 24 h. The solvent was removed in vacuo, the mixture was azeotroped with toluene and purified by chromatography (silica, CH2Cl2-MeOH—AcOH as eluent) to give the title compound (22 mg) as a white solid.

Aufarbeitung

  1. customThe solvent was removed in vacuo
  2. customthe mixture was azeotroped with toluene
  3. custompurified by chromatography (silica, CH2Cl2-MeOH—AcOH as eluent)

Quellen und Nachweise

ORD-Eintrag
ord-27a99210d77d48b3832c6c33a4259644
Quelldatensatz
uspto-grants-2012_04
Patentnummer
US08163727B2

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