Propionitrile → 2-Methyl-3-oxo-3-(4-(trifluoromethyl)phenyl)propionitrile

HRID 1695182

Reaktionsgleichung

Reaktionsgleichung von HRID 1695182
[NH2:1][C:2]1[CH:6]=[CH:5]NN=1.CO[C:9](=[O:20])[C:10]1[CH:15]=[CH:14][C:13]([C:16]([F:19])([F:18])[F:17])=[CH:12][CH:11]=1.[H-].[Na+].C(#N)CC>>[CH3:5][CH:6]([C:9](=[O:20])[C:10]1[CH:11]=[CH:12][C:13]([C:16]([F:17])([F:18])[F:19])=[CH:14][CH:15]=1)[C:2]#[N:1]

Komponenten

5

Edukt 4

HCID 7854PropionitrileHCID 24758Sodium hydrideHCID 520447Methyl 4-(trifluoromethyl)benzoateHCID 178418806HCID 178418806, Verbindung

Produkt 1

HCID 431572662-Methyl-3-oxo-3-(4-(trifluoromethyl)phenyl)propionitrileAusbeute 96 %

Versuchsvorschrift

The product was prepared according to the general procedure for aminopyrazole synthesis (route A1) from 4-trifluoromethyl-benzoic acid methyl ester (3.0 g, 14.7 mmol, 1.0 eq), NaH (1.2 g, 29.4 mmol, 2.0 eq) and propionitrile (4.9 mL, 69.4 mmol, 4.7 eq). The crude product was extracted with DCM and used in the following step without further purification (3.2 g, yield: 96%).

Aufarbeitung

  1. customThe product was prepared
  2. extractionThe crude product was extracted with DCM
  3. customused in the following step without further purification (3.2 g, yield: 96%)

Quellen und Nachweise

ORD-Eintrag
ord-bd720de13d4141079f412edd57df2be6
Quelldatensatz
uspto-grants-2012_04
Patentnummer
US08163729B2

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