2-Carbomethoxypyridine → Pyridine-2-carbonyl cyanide

Reaktionsgleichung

[NH2:1][C:2]1C=CNN=1.COC(=O)C1C=CC(OCC2CC2)=C(Cl)C=1.CO[C:25]([C:27]1[CH:32]=[CH:31][CH:30]=[CH:29][N:28]=1)=[O:26]>>[O:26]=[C:25]([C:27]1[CH:32]=[CH:31][CH:30]=[CH:29][N:28]=1)[C:2]#[N:1]

Komponenten

Edukt 3

HCID 755692-Carbomethoxypyridine

HCID 67015924HCID 67015924, Verbindung

HCID 178418806HCID 178418806, Verbindung

Produkt 1

HCID 13111406Pyridine-2-carbonyl cyanideAusbeute 69 %

Versuchsvorschrift

The product was prepared according to the general procedure for aminopyrazole synthesis (route A1) from pyridine-2-carboxylic acid methyl ester (3.0 g, 21.9 mmol, 1.0 eq). The crude was precipitated from HCl to give the title product as a solid (2.2 g, yield: 69%) which was used directly for the next step.