HCID 17887686, Verbindung → 3-(Difluoromethoxy)-β-oxobenzenepropanenitrile

Reaktionsgleichung

[NH2:1][C:2]1[CH:6]=CNN=1.COC(=O)C1C=CC(OCC2CC2)=C(Cl)C=1.CO[C:25](=[O:36])[C:26]1[CH:31]=[CH:30][CH:29]=[C:28]([O:32][CH:33]([F:35])[F:34])[CH:27]=1>>[F:35][CH:33]([F:34])[O:32][C:28]1[CH:27]=[C:26]([C:25](=[O:36])[CH2:6][C:2]#[N:1])[CH:31]=[CH:30][CH:29]=1

Komponenten

Edukt 3

HCID 17887686HCID 17887686, Verbindung

HCID 67015924HCID 67015924, Verbindung

HCID 178418806HCID 178418806, Verbindung

Produkt 1

HCID 431238303-(Difluoromethoxy)-β-oxobenzenepropanenitrile

Versuchsvorschrift

The product was prepared according to the general procedure for aminopyrazole synthesis (route A1 bis) from 3-difluoromethoxy-benzoic acid methyl ester (1.5 g, 7.4 mmol, 1.0 eq). The crude was precipitated by addition of aqueous HCl to give the product which was used directly for the next step.