Acetonitrile → 3-(6-Methoxy-naphthalen-2-yl)-3-oxo-propionitrile

HRID 1695219Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1695219
CO[C:3]([C:5]1[CH:14]=[CH:13][C:12]2[C:7](=[CH:8][CH:9]=[C:10]([O:15][CH3:16])[CH:11]=2)[CH:6]=1)=[O:4].[H-].[Na+].[C:19](#[N:21])[CH3:20]>C1(C)C=CC=CC=1>[CH3:16][O:15][C:10]1[CH:11]=[C:12]2[C:7](=[CH:8][CH:9]=1)[CH:6]=[C:5]([C:3](=[O:4])[CH2:20][C:19]#[N:21])[CH:14]=[CH:13]2

Komponenten

5

Edukt 3

HCID 6342AcetonitrileHCID 24758Sodium hydrideHCID 604020Methyl 6-methoxy-2-naphthoate

Produkt 1

HCID 671886013-(6-Methoxy-naphthalen-2-yl)-3-oxo-propionitrile

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 1140TolueneLösungsmittel

Reaktionsbedingungen

Temperatur
90 °C

Versuchsvorschrift

To a solution of 6-methoxy-naphthalene-2-carboxylic acid methyl ester (1.0 g, 4.7 mmol) in dry toluene (8 mL), NaH (0.55 mg, 9.4 mmol) were added and the mixture was heated at 90° C. To the hot solution, acetonitrile (1.2 mL) was added dropwise. The reaction was then heated for 18 hours and the product precipitated from the reaction mixture as its sodium salt.

Aufarbeitung

  1. temperatureThe reaction was then heated for 18 hours
  2. customthe product precipitated from the reaction mixture as its sodium salt

Quellen und Nachweise

ORD-Eintrag
ord-fd27605a8f18448884a75736b5b66078
Quelldatensatz
uspto-grants-2012_04
Patentnummer
US08163729B2

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