Methanol → Methyl 2-(difluoromethoxy)benzoate

HRID 1695245Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1695245
[F:1][CH:2]([F:13])[O:3][C:4]1[CH:12]=[CH:11][CH:10]=[CH:9][C:5]=1[C:6]([OH:8])=[O:7].S(=O)(=O)(O)O.[CH3:19]O>>[CH3:19][O:7][C:6](=[O:8])[C:5]1[CH:9]=[CH:10][CH:11]=[CH:12][C:4]=1[O:3][CH:2]([F:13])[F:1]

Komponenten

4

Edukt 3

HCID 887MethanolHCID 1118Sulfuric AcidHCID 20633482-(Difluoromethoxy)benzoic acid

Produkt 1

HCID 7018382Methyl 2-(difluoromethoxy)benzoateAusbeute 87 %

Versuchsvorschrift

2.0 g of 2-difluoromethoxy-benzoic acid (10.6 mmol, 1.0 eq) were dissolved in MeOH (15 mL) and a catalytic quantity of sulfuric acid was added; the mixture was heated at reflux overnight. The solvent was then evaporated and the residue was dissolved in DCM and washed with saturated NaHCO3. The organic phase was dried and evaporated to give 1.9 g of title product (yield 87%).

Aufarbeitung

  1. temperaturethe mixture was heated
  2. temperatureat reflux overnight
  3. customThe solvent was then evaporated
  4. dissolutionthe residue was dissolved in DCM
  5. washwashed with saturated NaHCO3
  6. customThe organic phase was dried
  7. customevaporated

Quellen und Nachweise

ORD-Eintrag
ord-efde82da3b744d7a978bcc6d18f39944
Quelldatensatz
uspto-grants-2012_04
Patentnummer
US08163729B2

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