Triazabicyclodecene → HCID 66646622, Verbindung

HRID 1695463

Reaktionsgleichung

Reaktionsgleichung von HRID 1695463
CO[C:3]([C:5]1[CH:9]=[C:8]([O:10][CH2:11][C:12]2[C:13]([C:18]3[CH:23]=[CH:22][CH:21]=[CH:20][N:19]=3)=[N:14][O:15][C:16]=2[CH3:17])[N:7]([CH3:24])[N:6]=1)=[O:4].[NH2:25][C@H:26]([CH2:28][OH:29])[CH3:27].N12CCCNC1=NCCC2>C1(C)C=CC=CC=1>[OH:29][CH2:28][C@@H:26]([NH:25][C:3]([C:5]1[CH:9]=[C:8]([O:10][CH2:11][C:12]2[C:13]([C:18]3[CH:23]=[CH:22][CH:21]=[CH:20][N:19]=3)=[N:14][O:15][C:16]=2[CH3:17])[N:7]([CH3:24])[N:6]=1)=[O:4])[CH3:27]

Komponenten

5

Edukt 3

HCID 79873TriazabicyclodeceneHCID 80307L-AlaninolHCID 666463331-methyl-5-(5-methyl-3-pyridin-2-yl-isoxazol-4-ylmethoxy)-1H-pyrazole-3-carboxylic acid methyl ester

Produkt 1

HCID 66646622HCID 66646622, VerbindungAusbeute 97,6 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 1140TolueneLösungsmittel

Versuchsvorschrift

To a solution of 1-methyl-5-(5-methyl-3-pyridin-2-yl-isoxazol-4-ylmethoxy)-1H-pyrazole-3-carboxylic acid methyl ester (80 mg, 0.24 mmol) and L-alaninol (24 mg, 0.32 mmol) in toluene (1 mL) was added 1,5,7-triazabicyclo[4.4.0]dec-5-ene (14 mg, 0.1 mmol) and the reaction was stirred at room temperature under argon overnight. The mixture was evaporated and purification by chromatography (silica, dichloromethane:methanol=100:0 to 9:1) afforded the title compound (87 mg, 96%) which was obtained as a colorless oil. MS: m/e=372.2 [M+H]+.

Aufarbeitung

  1. customThe mixture was evaporated
  2. custompurification by chromatography (silica, dichloromethane:methanol=100:0 to 9:1)

Quellen und Nachweise

ORD-Eintrag
ord-68ece5b06ab749589823bad744a31fdc
Quelldatensatz
uspto-grants-2012_04
Patentnummer
US08163728B2

Verknüpfte Notizen

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