4-methylpiperazine-1-sulfonyl Chloride → HCID 178481112, Verbindung
Reaktionsgleichung
[C@H:1]1([NH:11][C:12]2[O:13][CH2:14][C:15]3[CH:21]=[C:20]([NH2:22])[CH:19]=[CH:18][C:16]=3[N:17]=2)[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH2:4][CH2:3][CH2:2]1.[CH3:23][N:24]1[CH2:29][CH2:28][N:27]([S:30](Cl)(=[O:32])=[O:31])[CH2:26][CH2:25]1>>[C@H:1]1([NH:11][C:12]2[O:13][CH2:14][C:15]3[CH:21]=[C:20]([NH:22][S:30]([N:27]4[CH2:28][CH2:29][N:24]([CH3:23])[CH2:25][CH2:26]4)(=[O:32])=[O:31])[CH:19]=[CH:18][C:16]=3[N:17]=2)[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH2:4][CH2:3][CH2:2]1Komponenten
3
Versuchsvorschrift
Prepared from (R)-N2-(1,2,3,4-tetrahydro-naphthalen-1-yl)-4H-benzo[d][1,3]oxazine-2,6-diamine (Example 33) (100 mg, 0.341 mmol) and 4-methyl-piperazine-1-sulfonyl chloride (CAS 1688-95-5) (74 mg, 0.375 mmol) according to the procedure described for Example 27. Obtained the title compound as a light brown oil (94 mg, 61%), MS (ISP) m/e=456.3 [(M+H)+].
Quellen und Nachweise
- ORD-Eintrag
- ord-89712cf54ec446c58f4aa517cf70f41b
- Quelldatensatz
- uspto-grants-2012_04
- DOI