Benzenesulfonyl chloride → N-[5-bromo-2-(ethyloxy)-3-pyridinyl]benzenesulfonamide

HRID 1695754Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1695754
[Br:1][C:2]1[CH:3]=[C:4]([NH2:11])[C:5]([O:8][CH2:9][CH3:10])=[N:6][CH:7]=1.[C:12]1([S:18](Cl)(=[O:20])=[O:19])[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1>N1C=CC=CC=1>[Br:1][C:2]1[CH:3]=[C:4]([NH:11][S:18]([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)(=[O:20])=[O:19])[C:5]([O:8][CH2:9][CH3:10])=[N:6][CH:7]=1

Komponenten

4

Edukt 2

HCID 7369Benzenesulfonyl chlorideHCID 532116995-Bromo-2-ethoxypyridin-3-amine

Produkt 1

HCID 59860135N-[5-bromo-2-(ethyloxy)-3-pyridinyl]benzenesulfonamide

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 1049PyridineLösungsmittel

Versuchsvorschrift

A solution of 5-bromo-2-(ethyloxy)-3-pyridinamine (1.45 g) in anhydrous pyridine (15 ml) was treated with benzenesulfonyl chloride (1.03 ml) then stirred at RT for 20 hr. The reaction was evaporated to dryness and the residue was purified by column chromatography on silica, eluting with 30% hexanes in DCM, to give the title compound (1.86 g).

Aufarbeitung

  1. customThe reaction was evaporated to dryness
  2. customthe residue was purified by column chromatography on silica
  3. washeluting with 30% hexanes in DCM

Quellen und Nachweise

ORD-Eintrag
ord-087614375e224ad2a79c1264e1426db0
Quelldatensatz
uspto-grants-2012_04
Patentnummer
US08163743B2

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