3,3-Dimethylbutylamine → HCID 178444764, Verbindung

HRID 1695930

Reaktionsgleichung

Reaktionsgleichung von HRID 1695930
[N:1]1([CH2:7][CH2:8][NH:9][C:10]2[C:17]([F:18])=[CH:16][CH:15]=[CH:14][C:11]=2[CH:12]=O)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[CH3:19][C:20]([CH3:25])([CH3:24])[CH2:21][CH2:22][NH2:23]>C1(C)C=CC=CC=1>[CH3:19][C:20]([CH3:25])([CH3:24])[CH2:21][CH2:22]/[N:23]=[CH:12]/[C:11]1[CH:14]=[CH:15][CH:16]=[C:17]([F:18])[C:10]=1[NH:9][CH2:8][CH2:7][N:1]1[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1

Komponenten

4

Edukt 2

HCID 197093,3-DimethylbutylamineHCID 577744132-(2-(Piperidin-1-yl)ethylamino)-3-fluorobenzaldehyde

Produkt 1

HCID 178444764HCID 178444764, VerbindungAusbeute 95,9 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 1140TolueneLösungsmittel

Versuchsvorschrift

Crude 2-(2-(piperidin-1-yl)ethylamino)-3-fluorobenzaldehyde (372 mg, 1.486 mmol) and 3,3-dimethylbutan-1-amine (225.6 mg, 300.0 μL, 2.229 mmol) were stirred in toluene (7 mL) with 4A MS at RT overnight. The mixture was filtered and the volatiles were removed on rotary evaporator at 40° C. to give 475 mg of crude 2-((E)-(3,3-dimethylbutylimino)methyl)-6-fluoro-N-(2-(piperidin-1-yl)ethyl)benzenamine which was used directly in the next step.

Aufarbeitung

  1. filtrationThe mixture was filtered
  2. customthe volatiles were removed on rotary evaporator at 40° C.

Quellen und Nachweise

ORD-Eintrag
ord-a3061cb10b7e44e583edfa5987822f99
Quelldatensatz
uspto-grants-2012_04
Patentnummer
US08163737B2

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