Hydrochloric Acid → ((1S,3R)-3-aminocyclohexyl)methanol hydrochloride

HRID 1696214Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1696214
C(OC(=O)[NH:7][C@H:8]1[CH2:13][CH2:12][CH2:11][C@@H:10]([CH2:14][OH:15])[CH2:9]1)(C)(C)C.[ClH:17]>CCOC(C)=O>[ClH:17].[NH2:7][C@@H:8]1[CH2:13][CH2:12][CH2:11][C@H:10]([CH2:14][OH:15])[CH2:9]1

Komponenten

4

Edukt 2

HCID 313Hydrochloric AcidHCID 83823767tert-Butyl ((1S,3R)-3-(hydroxymethyl)cyclohexyl)carbamate

Produkt 1

HCID 67278446((1S,3R)-3-aminocyclohexyl)methanol hydrochloride

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8857Ethyl AcetateLösungsmittel2×

Versuchsvorschrift

To a solution of tert-butyl[cis-3-(hydroxymethyl)cyclohexyl]carbamate (311 mg) in EtOAc (3.1 ml) was added 4M HCl in EtOAc which was stirred at ambient temperature for 1 hour. Resulting precipitates were collected by filtration and washed with diisopropyl ether to give [cis-3-aminocyclohexyl]methanol hydrochloride (236 mg) as a white powder.

Aufarbeitung

  1. customResulting
  2. customprecipitates
  3. filtrationwere collected by filtration
  4. washwashed with diisopropyl ether

Quellen und Nachweise

ORD-Eintrag
ord-bcfeb085017d4d2ca7c36e2e73060efe
Quelldatensatz
uspto-grants-2012_04
Patentnummer
US08163767B2

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