2'-Nitro-4'-(trifluoromethyl)-[1,1'-biphenyl]-3-acetic acid ethyl ester → 2'-Amino-4'-(trifluoromethyl)-[1,1'-biphenyl]-3-acetic acid ethyl ester
Reaktionsgleichung
[CH2:1]([O:3][C:4](=[O:25])[CH2:5][C:6]1[CH:7]=[C:8]([C:12]2[CH:17]=[CH:16][C:15]([C:18]([F:21])([F:20])[F:19])=[CH:14][C:13]=2[N+:22]([O-])=O)[CH:9]=[CH:10][CH:11]=1)[CH3:2]>C1COCC1.[Ni]>[CH2:1]([O:3][C:4](=[O:25])[CH2:5][C:6]1[CH:7]=[C:8]([C:12]2[CH:17]=[CH:16][C:15]([C:18]([F:20])([F:19])[F:21])=[CH:14][C:13]=2[NH2:22])[CH:9]=[CH:10][CH:11]=1)[CH3:2]Komponenten
4
Edukt 1
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 2
Versuchsvorschrift
2′-Nitro-4′-(trifluoromethyl)-[1,1′-biphenyl]-3-acetic acid ethyl ester (107 mg, 0.30 mmol) in THF (6 mL) was treated with about 150 mg of Raney® nickel (50 wt % in H2O). The reaction was shaken on a Parr apparatus under 50 psi of H2. After 4.5 h, another 200 mg of Raney® nickel was added and the reaction was shaken an additional 2 h under 50 psi H2. The reaction mixture was filtered through Celite®, concentrated in vacuo and purified via column chromatography to afford 2′-amino-4′-(trifluoromethyl)-[1,1′-biphenyl]-3-acetic acid ethyl ester (58 mg, 59% yield). MS (ESI) m/z: 324.2 (M+H+).