Hydrochloric Acid → 2-Mercapto-4-methoxyphenol

HRID 1696714

Reaktionsgleichung

Reaktionsgleichung von HRID 1696714
[OH-].[Na+].[CH3:3][O:4][C:5]1[CH:6]=[CH:7][C:8]2[O:12]C(=O)[S:10][C:9]=2[CH:14]=1.Cl>C(O)C>[SH:10][C:9]1[CH:14]=[C:5]([O:4][CH3:3])[CH:6]=[CH:7][C:8]=1[OH:12]

Komponenten

5

Edukt 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 1370241,3-Benzoxathiol-2-one, 5-methoxy-

Produkt 1

HCID 127877572-Mercapto-4-methoxyphenolAusbeute 100 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Reaktionsbedingungen

Temperatur
65 °C

Versuchsvorschrift

Aqueous 2 N sodium hydroxide solution (44.7 mL) was added to an ethanol solution of the compound (7.76 g, 42.6 mmol) synthesized in the above (1), and stirred in a nitrogen atmosphere at 65° C. for 1.5 hours. The reaction liquid was neutralized with aqueous 5 N hydrochloric acid solution, and extracted twice with chloroform. The organic layer was dried with magnesium sulfate, and concentrated under reduced pressure to obtain the entitled compound (7.4 g, 100%) as a yellow oil.

Aufarbeitung

  1. customThe reaction liquid
  2. extractionextracted twice with chloroform
  3. dry with materialThe organic layer was dried with magnesium sulfate
  4. concentrationconcentrated under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-80fa6b369adb4d00944c6bf0b36ca069
Quelldatensatz
uspto-grants-2012_04
Patentnummer
US08163770B2

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