Ammonia → HCID 67274431, Verbindung
Reaktionsgleichung
[CH3:1][O:2][CH2:3][CH2:4][C:5]1[S:9][C:8]([S:10](Cl)(=[O:12])=[O:11])=[CH:7][C:6]=1[CH3:14].[NH3:15]>CC(C)=O>[CH3:1][O:2][CH2:3][CH2:4][C:5]1[S:9][C:8]([S:10]([NH2:15])(=[O:12])=[O:11])=[CH:7][C:6]=1[CH3:14]Komponenten
4
Edukt 2
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Versuchsvorschrift
To a solution of 1.40 g (55 mM) 5-(2-methoxy-ethyl)-4-methyl-thiophene-2-sulfonyl chloride in 20 ml acetone was added 5 ml of an aqueous solution of ammonia (25%) and the mixture was stirred at room temperature for 1 h. The mixture was partitioned between water and ethyl acetate. The phases were separated and the organic phase was dried over sodium sulfate and evaporated. The residue purified by chromatography on silica gel crystallized form cyclohexane/diethyl ether to yield 0.89 g of the title compound as light red solid. MS (ISN) M−H+=233.8