2-Chloro-4-hydrazinylpyridine → (2S,4R)-4-(2-Chloro-benzenesulfonyl)-1-[2-(2-chloro-pyridin-4-yl)-5-methyl-2H-pyrazol-3-yl]-pyrrolidine-2-carboxylic Acid Methyl Ester

Beteiligte Stoffe

Rolle	Name	HCID	Einwaage
Edukt	2-Chloro-4-hydrazinylpyridine	HCID 21106442	—
Edukt	(2S,4R)-methyl 4-(2-chlorophenylsulfonyl)-1-(3-oxobutanethioyl)pyrrolidine-2-carboxylate	HCID 86646820	—
Produkt	(2S,4R)-4-(2-Chloro-benzenesulfonyl)-1-[2-(2-chloro-pyridin-4-yl)-5-methyl-2H-pyrazol-3-yl]-pyrrolidine-2-carboxylic Acid Methyl Ester	HCID 86646821	—

Reaktionsschritte

In analogy to the procedure described in example 192 h, (2S,4R)-4-(2-chloro-benzenesulfonyl)-1-(3-oxo-thiobutyryl)-pyrrolidine-2-carboxylic acid methyl ester (example 253c) was reacted with (2-chloro-pyridin-4-yl)-hydrazine (CAS Reg. No. 700811-29-6) to give the title compound as colorless solid. MS (ESI): m/z=495.1 [M+H]+.

Herkunft & Nachweise

DOI	10.6084/m9.figshare.5104873.v1
Patentnummer	US08163793B2
Quelldatensatz	uspto-grants-2012_04
ORD ID	ord-050044ecae0b4b68926973c897924ca0
Quellennotiz	uspto-grants-2012_04