HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
m-Tolylhydrazinium(1+) chloride → (2S,4R)-1-(5-Methyl-2-m-tolyl-2H-pyrazol-3-yl)-4-(2-trifluoromethyl-benzenesulfonyl)-pyrrolidine-2-carboxylic Acid Methyl Ester
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | m-Tolylhydrazinium(1+) chloride | HCID 71562 | — |
| Edukt | (2S,4R)-1-(3-oxo-thiobutyryl)-4-(2-trifluoromethyl-benzenesulfonyl)-pyrrolidine-2-carboxylic acid methyl ester | HCID 86646823 | — |
| Produkt | (2S,4R)-1-(5-Methyl-2-m-tolyl-2H-pyrazol-3-yl)-4-(2-trifluoromethyl-benzenesulfonyl)-pyrrolidine-2-carboxylic Acid Methyl Ester | HCID 66770934 | — |
Reaktionsschritte
In analogy to the procedure described in example 192 h, (2S,4R)-1-(3-oxo-thiobutyryl)-4-(2-trifluoromethyl-benzenesulfonyl)-pyrrolidine-2-carboxylic acid methyl ester (example 192 g) was reacted with 3-methylphenylhydrazine hydrochloride (CAS Reg. No. 637-04-7) to give the title compound as yellow solid. MS (ESI): m/z=508.1 [M+H]+.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US08163793B2 |
| Quelldatensatz | uspto-grants-2012_04 |
| ORD ID | ord-81ded90e1f264a5db6853219fb405e0b |
| Quellennotiz | uspto-grants-2012_04 |