HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Hydrazine hydrate (1:1) → (2S,4R)-1-(5-Methyl-1H-pyrazol-3-yl)-4-(2-trifluoromethyl-benzenesulfonyl)-pyrrolidine-2-carboxylic Acid Methyl Ester
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Hydrazine hydrate (1:1) | HCID 24654 | — |
| Edukt | (2S,4R)-1-(3-oxo-thiobutyryl)-4-(2-trifluoromethyl-benzenesulfonyl)-pyrrolidine-2-carboxylic acid methyl ester | HCID 86646823 | — |
| Produkt | (2S,4R)-1-(5-Methyl-1H-pyrazol-3-yl)-4-(2-trifluoromethyl-benzenesulfonyl)-pyrrolidine-2-carboxylic Acid Methyl Ester | HCID 66771974 | — |
Reaktionsschritte
In analogy to the procedure described in example 192 h, (2S,4R)-1-(3-oxo-thiobutyryl)-4-(2-trifluoromethyl-benzenesulfonyl)-pyrrolidine-2-carboxylic acid methyl ester (example 192 g) was reacted with hydrazine monohydrate (CAS Reg. No. 7803-57-8) to give the title compound as yellow solid.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US08163793B2 |
| Quelldatensatz | uspto-grants-2012_04 |
| ORD ID | ord-6cbb45c625794b51892fffe0eee1d125 |
| Quellennotiz | uspto-grants-2012_04 |