1-Boc-1-methylhydrazine → (2S,4R)-1-[3-(tert-Butoxycarbonyl-methyl-hydrazono)-thiobutyryl]-4-(2-trifluoromethyl-benzenesulfonyl)-pyrrolidine-2-carboxylic Acid Methyl Ester

HRID 1697588

Reaktionsgleichung

Reaktionsgleichung von HRID 1697588
[CH3:1][O:2][C:3]([C@@H:5]1[CH2:9][C@@H:8]([S:10]([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=2[C:19]([F:22])([F:21])[F:20])(=[O:12])=[O:11])[CH2:7][N:6]1[C:23](=[S:28])[CH2:24][C:25](=O)[CH3:26])=[O:4].[C:29]([O:33][C:34]([N:36]([CH3:38])[NH2:37])=[O:35])([CH3:32])([CH3:31])[CH3:30]>>[CH3:1][O:2][C:3]([C@@H:5]1[CH2:9][C@@H:8]([S:10]([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=2[C:19]([F:22])([F:20])[F:21])(=[O:11])=[O:12])[CH2:7][N:6]1[C:23](=[S:28])[CH2:24][C:25](=[N:37][N:36]([C:34]([O:33][C:29]([CH3:32])([CH3:31])[CH3:30])=[O:35])[CH3:38])[CH3:26])=[O:4]

Komponenten

3

Edukt 2

HCID 37482801-Boc-1-methylhydrazineHCID 86646823(2S,4R)-1-(3-oxo-thiobutyryl)-4-(2-trifluoromethyl-benzenesulfonyl)-pyrrolidine-2-carboxylic acid methyl ester

Produkt 1

HCID 86646836(2S,4R)-1-[3-(tert-Butoxycarbonyl-methyl-hydrazono)-thiobutyryl]-4-(2-trifluoromethyl-benzenesulfonyl)-pyrrolidine-2-carboxylic Acid Methyl Ester

Versuchsvorschrift

In analogy to the procedure described in example 192 h, (2S,4R)-1-(3-oxo-thiobutyryl)-4-(2-trifluoromethyl-benzenesulfonyl)-pyrrolidine-2-carboxylic acid methyl ester (example 192 g) was reacted with N-methyl-hydrazinecarboxylic acid tert-butyl ester (CAS Reg. No. 21075-83-2) to give the title compound as off-white solid. MS (ESI): m/z=566.2 [M+H]+.

Quellen und Nachweise

ORD-Eintrag
ord-fabb3c98ef5a4d96b3a86a8a2a243298
Quelldatensatz
uspto-grants-2012_04
Patentnummer
US08163793B2

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