HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Lawesson's reagent → 4-{5-[(2S,4R)-2-Methoxycarbonyl-4-(2-trifluoromethyl-benzenesulfonyl)-pyrrolidin-1-yl]-3-methyl-pyrazol-1-yl}-piperidine-1-carboxylic Acid Benzyl Ester
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Lawesson's reagent | HCID 87949 | — |
| Edukt | Benzyl 4-hydrazinylpiperidine-1-carboxylate | HCID 21098319 | — |
| Edukt | (2S,4R)-1-(3-oxo-butyryl)-4-(2-trifluoromethyl-benzenesulfonyl)-pyrrolidine-2-carboxylic acid methyl ester | HCID 86646859 | — |
| Produkt | 4-{5-[(2S,4R)-2-Methoxycarbonyl-4-(2-trifluoromethyl-benzenesulfonyl)-pyrrolidin-1-yl]-3-methyl-pyrazol-1-yl}-piperidine-1-carboxylic Acid Benzyl Ester | HCID 66770398 | — |
Reaktionsschritte
In analogy to the procedure described in example 308d, (2S,4R)-1-(3-oxo-butyryl)-4-(2-trifluoromethyl-benzenesulfonyl)-pyrrolidine-2-carboxylic acid methyl ester (example 192f) was reacted with Lawesson's reagent (CAS Reg. No. 19172-47-5) and 4-hydrazino-piperidine-1-carboxylic acid benzyl ester (CAS Reg. No. 280111-51-5) to give the title compound as yellow oil.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US08163793B2 |
| Quelldatensatz | uspto-grants-2012_04 |
| ORD ID | ord-9b56101290c04bc299c08046e3f217fe |
| Quellennotiz | uspto-grants-2012_04 |