5-Indolylboronic acid → HCID 59239347, Verbindung
Reaktionsgleichung
C([CH:4]1[C:9]2[N:10]=[C:11](Cl)[N:12]=[C:13]([N:14]3[CH2:19][CH2:18][O:17][CH2:16][C@@H:15]3[CH3:20])[C:8]=2[CH2:7][CH2:6][N:5]1[C:22]([O:24][C:25]([CH3:28])([CH3:27])[CH3:26])=[O:23])C=C.[NH:29]1[C:37]2[C:32](=[CH:33][C:34](B(O)O)=[CH:35][CH:36]=2)[CH:31]=[CH:30]1>>[NH:29]1[C:37]2[C:32](=[CH:33][C:34]([C:11]3[N:12]=[C:13]([N:14]4[CH2:19][CH2:18][O:17][CH2:16][C@@H:15]4[CH3:20])[C:8]4[CH2:7][CH2:6][N:5]([C:22]([O:24][C:25]([CH3:27])([CH3:26])[CH3:28])=[O:23])[CH2:4][C:9]=4[N:10]=3)=[CH:35][CH:36]=2)[CH:31]=[CH:30]1Komponenten
3
Versuchsvorschrift
Compound fm was prepared according to the procedure described in Example 2 step 2 by reacting tert-butyl 8-allyl-2-chloro-4-((S)-3-methylmorpholino)-5,6-dihydropyrido[3,4-d]pyrimidine-7(8H)-carboxylate with 1H-indol-5-ylboronic acid. LC-MS: m/z=+450 (M+H)−.
Aufarbeitung
- customCompound fm was prepared
Quellen und Nachweise
- ORD-Eintrag
- ord-1c7000a287554edab103597ff670708c
- Quelldatensatz
- uspto-grants-2012_04