Hydrochloric Acid → (S)-1-(2-methanesulfonyl-thiazol-5-yl)-propylamine hydrochloride

HRID 1698191Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1698191
[CH3:1][S:2]([C:5]1[S:6][C:7]([C@@H:10]([NH:13]S(C(C)(C)C)=O)[CH2:11][CH3:12])=[CH:8][N:9]=1)(=[O:4])=[O:3].[ClH:20]>CO.O1CCOCC1>[ClH:20].[CH3:1][S:2]([C:5]1[S:6][C:7]([C@@H:10]([NH2:13])[CH2:11][CH3:12])=[CH:8][N:9]=1)(=[O:3])=[O:4]

Komponenten

5

Edukt 2

HCID 313Hydrochloric AcidHCID 667274522-methyl-propane-2-sulfinic acid [(S)-1-(2-methanesulfonyl-thiazol-5-yl)-propyl]amide

Produkt 1

HCID 66727345(S)-1-(2-methanesulfonyl-thiazol-5-yl)-propylamine hydrochloride

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 887MethanolLösungsmittelHCID 312751,4-DioxaneLösungsmittel

Versuchsvorschrift

To a solution of 2-methyl-propane-2-sulfinic acid [(S)-1-(2-methanesulfonyl-thiazol-5-yl)-propyl]amide (80 mg, 0.3 mmol) in methanol (5 mL) was added a 4 N solution of hydrochloric acid (1 mL, 4 mmol) in dioxane. After 1 hour, the mixture was concentrated and diluted with dichloromethane (2 mL) followed by hexanes (10 mL), and concentrated to afford (S)-1-(2-methanesulfonyl-thiazol-5-yl)-propylamine hydrochloride.

Aufarbeitung

  1. concentrationthe mixture was concentrated
  2. additiondiluted with dichloromethane (2 mL)
  3. concentrationconcentrated

Quellen und Nachweise

ORD-Eintrag
ord-2bd659d9e8034dd4b0b8c4a493150bd6
Quelldatensatz
uspto-grants-2012_04
Patentnummer
US08163918B2

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