Hydrochloric Acid → (3-Bromo-1,2-oxazol-5-yl)methanamine hydrochloride

HRID 1698220Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1698220
[Br:1][C:2]1[CH:6]=[C:5]([CH2:7][NH:8]S(C(C)(C)C)=O)[O:4][N:3]=1.[ClH:15].O1CCOCC1>CO>[ClH:15].[Br:1][C:2]1[CH:6]=[C:5]([CH2:7][NH2:8])[O:4][N:3]=1

Komponenten

5

Edukt 3

HCID 313Hydrochloric AcidHCID 312751,4-DioxaneHCID 66727644HCID 66727644, Verbindung

Produkt 1

HCID 21292272(3-Bromo-1,2-oxazol-5-yl)methanamine hydrochloride

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

To a solution of 2-methyl-propane-2-sulfinic acid (3-bromo-isoxazol-5-ylmethyl)-amide (128 mg, 0.455 mmol) in MeOH (5 mL) was added a 4 M solution of HCl in dioxane (0.350 mL, 1.40 mmol) dropwise. After 2 hours and 10 minutes, the reaction mixture was concentrated in vacuo to afford the title compound which was used without further purification.

Aufarbeitung

  1. concentration10 minutes, the reaction mixture was concentrated in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-46796126241e4eaba574ee372fa87aef
Quelldatensatz
uspto-grants-2012_04
Patentnummer
US08163918B2

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