(2S,3S)-N-butyl-3-azido-2-hydroxyheptanamide → (2S,3S)-N-butyl-3-amino-2-hydroxyheptanamide

HRID 1698437Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1698437
[CH2:1]([NH:5][C:6](=[O:17])[C@@H:7]([OH:16])[C@@H:8]([N:13]=[N+]=[N-])[CH2:9][CH2:10][CH2:11][CH3:12])[CH2:2][CH2:3][CH3:4]>[C].[Pd].CO>[CH2:1]([NH:5][C:6](=[O:17])[C@@H:7]([OH:16])[C@@H:8]([NH2:13])[CH2:9][CH2:10][CH2:11][CH3:12])[CH2:2][CH2:3][CH3:4]

Komponenten

4

Edukt 1

HCID 59655565(2S,3S)-N-butyl-3-azido-2-hydroxyheptanamide

Produkt 1

HCID 59655570(2S,3S)-N-butyl-3-amino-2-hydroxyheptanamideAusbeute 94 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 178418390HCID 178418390, VerbindungKatalysatorHCID 887MethanolLösungsmittel

Versuchsvorschrift

To 30 ml of a methanol solution containing 304 mg (1.25 mmol) of (2S,3S)-N-butyl-3-azido-2-hydroxyheptanamide was added 30 mg of 5% palladium carbon, and the resulting mixture was stirred under hydrogen atmosphere for 18 hours. Insoluble materials were filtered off, and the filtrate was distilled under reduced pressure to obtain 254 mg (Yield: 94%) of the title compound.

Aufarbeitung

  1. filtrationInsoluble materials were filtered off
  2. distillationthe filtrate was distilled under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-fc673ca78c4f406ab2cf49eddd104304
Quelldatensatz
uspto-grants-2012_04
Patentnummer
US08163943B2

Notizen zur Reaktion

Wird geladen…