1,2-Dibromoethane → HCID 178477283, Verbindung

Temperatur

50 °C

1-Bromo-4-(ethylthio)benzene (0.5 g, 2.3 mmol) was added to a stirred mixture of magnesium turnings (1.96 g, 82 mmol) in THF (10 mL). 1,2-Dibromoethane (30 μL) was then added and the mixture was heated at reflux to initiate the reaction. A solution of 1-bromo-4-(ethylthio)benzene (18.2 g, 84 mmol) in THF (60 mL) was added at such a rate to maintain the reaction mixture at gentle reflux. The reaction mixture was then stirred at 50° C. for 90 min and cooled to ambient temp to give a 1.16M solution of 4-(ethylthio)phenylmagnesium bromide in THF which was used in the next reaction.

1. temperaturethe mixture was heated
2. temperatureat reflux
3. customthe reaction
4. temperatureto maintain the reaction mixture at gentle reflux
5. temperaturecooled to ambient temp

ORD-Eintrag

ord-98cd55c83df54854bb20f0310eca59fd

Quelldatensatz

uspto-grants-2012_04

DOI

10.6084/m9.figshare.5104873.v1

Patentnummer

US08163956B2