1,1'-Carbonyldiimidazole → 4,5-Dihydro-7H-imidazo[4,5,1-jk][4,1]benzoxazepine-2,7(1H)-dione
Reaktionsgleichung
[NH2:1][C:2]1[C:12]2[NH:11][CH2:10][CH2:9][O:8][C:7](=[O:13])[C:6]=2[CH:5]=[CH:4][CH:3]=1.[C:14](N1C=CN=C1)(N1C=CN=C1)=[O:15]>C1COCC1>[NH:1]1[C:2]2=[CH:3][CH:4]=[CH:5][C:6]3=[C:12]2[N:11]([CH2:10][CH2:9][O:8][C:7]3=[O:13])[C:14]1=[O:15]Komponenten
4
Edukt 2
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Versuchsvorschrift
To a solution of 200 mg (1.13 mmol) of 9-amino-2,3-dihydro-4,1-benzoxazepin-5(1H)-one in 20 mL of THF was added 280 mg (2 mmol) of 1,1′-carbonyldiimidazole and the reaction mixture was stirred overnight at room temperature. The reaction mixture was heated at 50° C. for 4 h and allowed to cool to room temperature. The reaction was concentrated in vacuo and the residue was dissolved in a mixture of ethyl acetate/n-hexane (1:1) and washed with water. The organics were dried over sodium sulfate, filtered, and concentrated in vacuo to give 286 mg (1.40 mmol, 70%) of the title compound.