Tetrahydrofuran → Methyl 2-oxo-2,3-dihydro-1H-benzo[d]imidazole-4-carboxylate

HRID 1698567Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1698567
[NH2:1][C:2]1[C:11]([NH2:12])=[CH:10][CH:9]=[CH:8][C:3]=1[C:4]([O:6][CH3:7])=[O:5].[O:13]1CCC[CH2:14]1>>[O:13]=[C:14]1[NH:12][C:11]2[CH:10]=[CH:9][CH:8]=[C:3]([C:4]([O:6][CH3:7])=[O:5])[C:2]=2[NH:1]1

Komponenten

3

Edukt 2

HCID 8028TetrahydrofuranHCID 5718252,3-Diaminobenzoic acid methyl ester

Produkt 1

HCID 22745204Methyl 2-oxo-2,3-dihydro-1H-benzo[d]imidazole-4-carboxylateAusbeute 84 %

Versuchsvorschrift

To a solution of methyl 2,3-diaminobenzoate (10.5 g, 63.2 mmol) in tetrahydrofuran (100 mL) was added N,N′carbonyldiimidazole (10.2 g, 63.2 mmol), and the mixture was stirred at room temperature for 60 hours. The resulting solid was collected by filtration and washed with ethyl acetate to give 10.2 g (53.1 mmol, 84.0%) of the title compound as a colorless crystal.

Aufarbeitung

  1. filtrationThe resulting solid was collected by filtration
  2. washwashed with ethyl acetate

Quellen und Nachweise

ORD-Eintrag
ord-e92ab6b4652c4729b09be4ed701c4878
Quelldatensatz
uspto-grants-2012_04
Patentnummer
US08163935B2

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