HCID 22387939, Verbindung → 2-Methyl-1H-imidazo[4,5-b]pyridine-5-carbonitrile

Reaktionsgleichung

ClC1C=C(Cl)C=CC=1C[N:5]1[C:9]2=[N:10][C:11]([C:14]#[N:15])=[CH:12][CH:13]=[C:8]2[N:7]=[C:6]1[CH3:16].ClC1C=C(Cl)C=CC=1CN1C2C(=NC(C#N)=CC=2)N=C1C>>[CH3:16][C:6]1[NH:7][C:8]2[C:9]([N:5]=1)=[N:10][C:11]([C:14]#[N:15])=[CH:12][CH:13]=2

Komponenten

Edukt 2

HCID 22387939HCID 22387939, Verbindung

HCID 22388114HCID 22388114, Verbindung

Produkt 1

HCID 223881362-Methyl-1H-imidazo[4,5-b]pyridine-5-carbonitrileAusbeute 290,6 %

Versuchsvorschrift

In the same manner as in the following Preparation Example 14-2, two isomers, 3-(2,4-dichlorobenzyl)-2-methyl-3H-imidazo[4,5-b]pyridine-5-carbonitrile (138 mg) and 1-(2,4-dichlorobenzyl)-2-methyl-1H-imidazo[4,5-b]pyridine-5-carbonitrile (67 mg were respectively obtained as pale-brown crystals from 2-methyl-1H-imidazo[4,5-b]pyridine-5-carbonitrile (200 mg).

Quellen und Nachweise

ORD-Eintrag: ord-889c6c41f25f49c2bb4d425624c16611
Quelldatensatz: uspto-grants-2002_02
DOI: 10.6084/m9.figshare.5104873.v1
Patentnummer: US06348474B1

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