Hydrochloric Acid → HCID 54335685, Verbindung
Reaktionsgleichung
[O:1]=[C:2]([C:7]([CH3:10])([CH3:9])[CH3:8])[C:3]([NH:5][CH3:6])=[O:4].Cl>CO.C(Cl)Cl>[OH:1][C@@H:2]([C:7]([CH3:10])([CH3:9])[CH3:8])[C:3]([NH:5][CH3:6])=[O:4]Komponenten
5
Edukt 2
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 2
Versuchsvorschrift
The experiment was carried out in an analogous manner to Example 1. The asymmetric hydrogenation of 55.0 g (0.384 mol) of 2-keto-3,3,N-trimethyl-butyramide in 270 ml of methanol and 30 ml of methylene chloride in the presence of a catalyst prepared from 296 mg (0.384 mmol) of [Ru(OAc)2((S)-BIPHEMP)] and 31 ml of a 0.025 molar methanolic hydrochloric acid solution gave, after crystallization, 34.4 g (62%) of (S)-2-hydroxy-3,3,N-trimethyl-butyramide, m.p.=60-62° C., [α]=−59.9° (c=1, CHCl3), ee=99.2%.
Aufarbeitung
- customgave
- customafter crystallization, 34.4 g (62%) of (S)-2-hydroxy-3,3,N-trimethyl-butyramide, m.p.=60-62° C., [α]=−59.9° (c=1, CHCl3), ee=99.2%
Quellen und Nachweise
- ORD-Eintrag
- ord-15a7b538dd284072a1e8b046786d3c00
- Quelldatensatz
- uspto-grants-2002_02
- Patentnummer
- US06348612B1
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