Rti 32 → HCID 10610260, Verbindung

HRID 1700263Notizen

Reaktionsgleichung

C1([C@H]2C[C@H]3N(C)[C@H](CC3)[C@H]2C(OC)=O)C=CC=CC=1.[C:20]1([CH3:39])[CH:25]=[CH:24][C:23]([C@H:26]2[CH2:32][C@H:31]3[N:33]([CH3:34])[C@H:28]([CH2:29][CH2:30]3)[C@H:27]2[C:35](OC)=[O:36])=[CH:22][CH:21]=1>>[CH:35]([C@H:27]1[C@@H:26]([C:23]2[CH:24]=[CH:25][C:20]([CH3:39])=[CH:21][CH:22]=2)[CH2:32][C@H:31]2[N:33]([CH3:34])[C@@H:28]1[CH2:29][CH2:30]2)=[O:36]

Komponenten

Edukt 2

HCID 125416Rti 32

HCID 170832Troparil

Produkt 1

HCID 10610260HCID 10610260, Verbindung

Versuchsvorschrift

Using a procedure similar to that described in Example 8, sub-part b, except replacing the compound 15 used therein with compound 16, the title compound 19 was prepared as a colorless oil: 1H NMR (CDCl3) δ1.70 (d, 1H. J=8.7 Hz), 1.60-1.78 (m, 1H), 1.89 (dt, 1H, J=3.9 and 12.9), 2.19 (s, 3H), 2.30 (s, 3H), 2.10-2.33 (m, 2H), 2.39-2.53 (m, 2H), 3.14 (dt, 1H, J=5.7 and 12.9 Hz), 3.36-3.45 (m, 1H), 3.46-3.55 (m, 1H), 7.10 (br s, 4H), 9.66 (d, 1H, J=3.3 Hz).

Quellen und Nachweise

ORD-Eintrag: ord-36acf04bcb834f2cb9c7fa6a026ae9a6
Quelldatensatz: uspto-grants-2002_02
DOI: 10.6084/m9.figshare.5104873.v1
Patentnummer: US06350758B1

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