Win 35428 → HCID 10490726, Verbindung

HRID 1700265

Reaktionsgleichung

C1([C@H]2C[C@H]3N(C)[C@H](CC3)[C@H]2C(OC)=O)C=CC=CC=1.[F:20][C:21]1[CH:26]=[CH:25][C:24]([C@H:27]2[CH2:33][C@H:32]3[N:34]([CH3:35])[C@H:29]([CH2:30][CH2:31]3)[C@H:28]2[C:36](OC)=[O:37])=[CH:23][CH:22]=1>>[CH:36]([C@H:28]1[C@@H:27]([C:24]2[CH:23]=[CH:22][C:21]([F:20])=[CH:26][CH:25]=2)[CH2:33][C@H:32]2[N:34]([CH3:35])[C@@H:29]1[CH2:30][CH2:31]2)=[O:37]

Komponenten

Edukt 2

HCID 105056Win 35428

HCID 170832Troparil

Produkt 1

HCID 10490726HCID 10490726, Verbindung

Versuchsvorschrift

Using a procedure similar to that described in Example 8, sub-part b, except replacing the compound 15 used therein with compound 17, the compound 20 was prepared as a colorless oil: 1H NMR (CDCl3) δ1.74 (d,1H, J=8.5), 1.64-1.82 (m,1H), 1.91 (dt,1H, J=3.8 and 12.7), 2.21 (s,3H), 2.10-2.33 (m,2H), 2.39-2.54 (m,2H), 3.16 (dt,1H, J=5.7 and 12.9), 3.40-3.48 (m,1H), 3.50-3.60 (m,1H), 7.00 (t, 2H, J=8.7), 7.19 (dd, 2H, J=6.0 and 8.4), 9.64 (d,1H, J=3.2).

Quellen und Nachweise

ORD-Eintrag: ord-4c3ebe47e4224c9d98157b987d28d108
Quelldatensatz: uspto-grants-2002_02
DOI: 10.6084/m9.figshare.5104873.v1
Patentnummer: US06350758B1

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