4-Nitrophenol → 1-TERT-BUTOXY-4-NITROBENZENE

HRID 1700273Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1700273
[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([OH:10])=[CH:6][CH:5]=1)([O-:3])=[O:2].[C:11]1([CH3:17])[CH:16]=CC=C[CH:12]=1>C(OCC)(=O)C>[C:11]([O:10][C:7]1[CH:8]=[CH:9][C:4]([N+:1]([O-:3])=[O:2])=[CH:5][CH:6]=1)([CH3:17])([CH3:16])[CH3:12]

Komponenten

4

Edukt 2

HCID 9804-NitrophenolHCID 1140Toluene

Produkt 1

HCID 109433951-TERT-BUTOXY-4-NITROBENZENE

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8857Ethyl AcetateLösungsmittel

Versuchsvorschrift

43.79 mmol of N-N-dimethylformamide di-tert-butyl acetal are added, at ambient temperature, to a solution of 10.78 mmol (1.5 g) of 4-nitrophenol in 10 ml of toluene. The reaction mixture is heated at reflux, with vigorous stirring, for 5 hours. The reaction mixture is diluted with ethyl acetate and then washed with water, with saturated aqueous sodium bicarbonate solution and then with 10% aqueous sodium chloride solution. The expected product is obtained by drying the organic phase and then concentrating.

Aufarbeitung

  1. temperatureThe reaction mixture is heated
  2. temperatureat reflux, with vigorous stirring, for 5 hours
  3. washwashed with water, with saturated aqueous sodium bicarbonate solution

Quellen und Nachweise

ORD-Eintrag
ord-e9af818f89a4420d97f95a114b81ae7d
Quelldatensatz
uspto-grants-2002_02
Patentnummer
US06350759B1

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