1-(6-Chloro-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-1-yl)cyclobutanecarboxaldehyde → HCID 18317883, Verbindung

HRID 1700383Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1700383
[Cl:1][C:2]1[CH:3]=[C:4]2[C:12](=[CH:13][CH:14]=1)[NH:11][C:10]1[CH:9]([C:15]3([CH:19]=[O:20])[CH2:18][CH2:17][CH2:16]3)[NH:8][CH2:7][CH2:6][C:5]2=1.[CH2:21]([Mg]Br)[CH3:22]>O1CCCC1>[Cl:1][C:2]1[CH:3]=[C:4]2[C:12](=[CH:13][CH:14]=1)[NH:11][C:10]1[CH:9]([C:15]3([CH:19]([OH:20])[CH2:21][CH3:22])[CH2:18][CH2:17][CH2:16]3)[NH:8][CH2:7][CH2:6][C:5]2=1

Komponenten

4

Edukt 2

HCID 183179861-(6-Chloro-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-1-yl)cyclobutanecarboxaldehydeHCID 178418443HCID 178418443, Verbindung

Produkt 1

HCID 18317883HCID 18317883, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel2×

Versuchsvorschrift

2.32 g of the compound obtained in Step A of Example 115 in 150 ml of tetrahydrofuran are stirred for 4 hours at −30° C., under an inert atmosphere, in the presence of 15 ml of a 1M solution of ethylmagnesium bromide in tetrahydrofuran. After returning to ambient temperature, the mixture is worked up in conventional manner, then concentrated under reduced pressure, enabling the expected product to be isolated.

Aufarbeitung

  1. customAfter returning to ambient temperature
  2. concentrationconcentrated under reduced pressure
  3. customto be isolated

Quellen und Nachweise

ORD-Eintrag
ord-f7e93ae2df364eb0a1ae40511447bdc3
Quelldatensatz
uspto-grants-2002_02
Patentnummer
US06350757B1

Notizen zur Reaktion

Wird geladen…