2,2-Dimethyl-5-[(3-oxo-5-phenyl-1-cyclohexenylamino)methylene]-[1,3]dioxane-4,6-dione → 7-Phenyl-1,4,5,6,7,8-hexahydroquinoline-4,5-dione

HRID 1700505Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1700505
CC1(C)O[C:6](=[O:8])[C:5](=[CH:9][NH:10][C:11]2[CH2:16][CH:15]([C:17]3[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=3)[CH2:14][C:13](=[O:23])[CH:12]=2)C(=O)O1>C1(OC2C=CC=CC=2)C=CC=CC=1>[C:17]1([CH:15]2[CH2:16][C:11]3[NH:10][CH:9]=[CH:5][C:6](=[O:8])[C:12]=3[C:13](=[O:23])[CH2:14]2)[CH:18]=[CH:19][CH:20]=[CH:21][CH:22]=1

Komponenten

3

Edukt 1

HCID 183175972,2-Dimethyl-5-[(3-oxo-5-phenyl-1-cyclohexenylamino)methylene]-[1,3]dioxane-4,6-dione

Produkt 1

HCID 183177747-Phenyl-1,4,5,6,7,8-hexahydroquinoline-4,5-dioneAusbeute 72,8 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 7583Diphenyl EtherLösungsmittel

Versuchsvorschrift

A solution of 2,2-dimethyl-5-[(3-oxo-5-phenyl-1-cyclohexenylamino)methylene]-[1,3]dioxane-4,6-dione (1.0 g) in diphenylether (15 ml) was stirred at 260-280° C. for 30 minutes. Under reduced pressure, the solvent was evaporated, and the resulting crystals were washed with petroleum ether. The crystals were recrystallized from ethanol to give crystals of 7-phenyl-1,4,5,6,7,8-hexahydroquinoline-4,5-dione (0.51 g).

Aufarbeitung

  1. customUnder reduced pressure, the solvent was evaporated
  2. washthe resulting crystals were washed with petroleum ether
  3. customThe crystals were recrystallized from ethanol

Quellen und Nachweise

ORD-Eintrag
ord-cef436510e1b4e6eadb1c68cb25939c5
Quelldatensatz
uspto-grants-2002_02
Patentnummer
US06350749B1

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