Hydrochloric Acid → 2-[(E)-[6-(furan-2-yl)-3-methyl-6,7-dihydro-5H-1-benzofuran-4-ylidene]amino]guanidine;hydrochloride

HRID 1700567Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1700567
[O:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[CH:6]1[CH2:15][C:14](=O)[C:9]2[C:10]([CH3:13])=[CH:11][O:12][C:8]=2[CH2:7]1.[C:17]([NH:20][NH2:21])([NH2:19])=[NH:18].[ClH:22].Cl>C(O)C>[ClH:22].[O:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[CH:6]1[CH2:15]/[C:14](=[N:21]\[NH:20][C:17]([NH2:19])=[NH:18])/[C:9]2[C:10]([CH3:13])=[CH:11][O:12][C:8]=2[CH2:7]1

Komponenten

5

Edukt 3

HCID 313Hydrochloric AcidHCID 183174076-(2-Furyl)-3-methyl-4,5,6,7-tetrahydrobenzofuran-4-oneHCID 178418668HCID 178418668, Verbindung

Produkt 1

HCID 1784311432-[(E)-[6-(furan-2-yl)-3-methyl-6,7-dihydro-5H-1-benzofuran-4-ylidene]amino]guanidine;hydrochlorideAusbeute 70 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Reaktionsbedingungen

Temperatur
90 °C

Versuchsvorschrift

To a mixture of 6-(2-furyl)-3-methyl-4,5,6,7-tetrahydrobenzofuran-4-one (0.22 g) and aminoguanidine hydrochloride (113 mg) were ethanol (20 ml) and 6N hydrochloric acid (0.088 ml), and the mixture was stirred at 90° C. for 2 hours and cooled. The reaction solution was concentrated under reduced pressure, and the residue was washed with ethanol, ethyl acetate and isopropylether, and dried to give (E)-6-(2-furyl)-4-guanidinoimino-3-methyl-4,5,6,7-tetrahydrobenzofuran hydrochloride (Compound 47) (0.22 g).

Aufarbeitung

  1. temperaturecooled
  2. concentrationThe reaction solution was concentrated under reduced pressure
  3. washthe residue was washed with ethanol, ethyl acetate and isopropylether
  4. customdried

Quellen und Nachweise

ORD-Eintrag
ord-9f57786235264c1ba6fd721005069136
Quelldatensatz
uspto-grants-2002_02
Patentnummer
US06350749B1

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