Hydrochloric Acid → HCID 178423650, Verbindung

HRID 1700569Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1700569
[CH3:1][C:2]1[S:6][C:5]([CH:7]2[CH2:16][C:15](=O)[C:10]3[C:11](C)=[CH:12][O:13][C:9]=3[CH2:8]2)=[CH:4][CH:3]=1.[C:18]([NH:21][NH2:22])([NH2:20])=[NH:19].[ClH:23].Cl.[CH2:25](O)C>>[ClH:23].[NH:21](/[N:22]=[C:15]1\[CH:16]([CH3:25])[CH:7]([C:5]2[S:6][C:2]([CH3:1])=[CH:3][CH:4]=2)[CH2:8][C:9]2[O:13][CH:12]=[CH:11][C:10]\1=2)[C:18]([NH2:20])=[NH:19]

Komponenten

5

Edukt 4

HCID 313Hydrochloric AcidHCID 702EthanolHCID 183175876-(5-Methyl-2-thienyl)-3-methyl-4,5,6,7-tetrahydrobenzofuran-4-oneHCID 178418668HCID 178418668, Verbindung

Produkt 1

HCID 178423650HCID 178423650, Verbindung

Reaktionsbedingungen

Temperatur
90 °C

Versuchsvorschrift

To a mixture of 6-(5-methyl-2-thienyl)-3-methyl-4,5,6,7-tetrahydrobenzofuran-4-one (0.18 g) and aminoguanidine hydrochloride (81 mg) were added ethanol (15 ml) and 6N hydrochloric acid (0.063 ml), and the mixture was stirred at 90° C. for 2 hours and cooled. The reaction solution was concentrated under reduced pressure, and the residue was washed with ethanol, ethyl acetate and isopropylether, and dried to give (E)-4-guanidinoimino-6-(5-methyl-2-thienyl)-5-methyl-4,5,6,7-tetrahydrobenzofuran hydrochloride (Compound 49) (0.18 g).

Aufarbeitung

  1. temperaturecooled
  2. concentrationThe reaction solution was concentrated under reduced pressure
  3. washthe residue was washed with ethanol, ethyl acetate and isopropylether
  4. customdried

Quellen und Nachweise

ORD-Eintrag
ord-b727f9491dd44d479cc28fa73c74fc5a
Quelldatensatz
uspto-grants-2002_02
Patentnummer
US06350749B1

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