Hydrochloric Acid → HCID 178479522, Verbindung

HRID 1700571Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1700571
[F:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]2[CH2:20][C:19](=O)[C:11]3[C:12]([C:15]([F:18])([F:17])[F:16])=[CH:13][O:14][C:10]=3[CH2:9]2)=[CH:4][CH:3]=1.[C:22]([NH:25][NH2:26])([NH2:24])=[NH:23].[ClH:27].Cl>C(O)C>[ClH:27].[F:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]2[CH2:20]/[C:19](=[N:26]\[NH:25][C:22]([NH2:24])=[NH:23])/[C:11]3[C:12]([C:15]([F:18])([F:17])[F:16])=[CH:13][O:14][C:10]=3[CH2:9]2)=[CH:4][CH:3]=1

Komponenten

5

Edukt 3

HCID 313Hydrochloric AcidHCID 183176886-(4-Fluorophenyl)-3-trifluoromethyl-4,5,6,7-tetrahydrobenzofuran-4-oneHCID 178418668HCID 178418668, Verbindung

Produkt 1

HCID 178479522HCID 178479522, VerbindungAusbeute 61,1 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Reaktionsbedingungen

Temperatur
90 °C

Versuchsvorschrift

To a mixture of 6-(4-fluorophenyl)-3-trifluoromethyl-4,5,6,7-tetrahydrobenzofuran-4-one (0.25 g) and aminoguanidine hydrochloride (93 mg) were ethanol (20 ml) and 6N hydrochloric acid (0.072 ml), and the mixture was stirred at 90° C. for 4 hours and cooled. The reaction solution was concentrated under reduced pressure, and the residue was washed with ethanol, ethyl acetate and isopropylether, and dried to give (E)-6-(4-fluorophenyl)-4-guanidinoimino-3-trifluoromethyl-4,5,6,7-tetrahydrobenzofuran hydrochloride (Compound 51) (0.20 g).

Aufarbeitung

  1. temperaturecooled
  2. concentrationThe reaction solution was concentrated under reduced pressure
  3. washthe residue was washed with ethanol, ethyl acetate and isopropylether
  4. customdried

Quellen und Nachweise

ORD-Eintrag
ord-bf33958d6d28477ab2e2478ffa8cc97b
Quelldatensatz
uspto-grants-2002_02
Patentnummer
US06350749B1

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