Hydrochloric Acid → HCID 178434187, Verbindung

HRID 1700671Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1700671
[Cl:1][C:2]1[S:3][C:4]([Cl:18])=[CH:5][C:6]=1[CH:7]1[CH2:15][C:14]2[NH:13][N:12]=[C:11]([CH3:16])[C:10]=2[C:9](=O)[CH2:8]1.Cl.[NH2:20][NH:21][C:22]([NH:24][OH:25])=[NH:23].Cl>C(O)C>[ClH:1].[Cl:1][C:2]1[S:3][C:4]([Cl:18])=[CH:5][C:6]=1[CH:7]1[CH2:15][C:14]2[NH:13][N:12]=[C:11]([CH3:16])[C:10]=2[C:9](=[N:20][NH:21][C:22](=[NH:23])[NH:24][OH:25])[CH2:8]1

Komponenten

5

Edukt 3

HCID 313Hydrochloric AcidHCID 178434193HCID 178434193, VerbindungHCID 178479533HCID 178479533, Verbindung

Produkt 1

HCID 178434187HCID 178434187, VerbindungAusbeute 156,8 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Reaktionsbedingungen

Temperatur
90 °C

Versuchsvorschrift

To a mixture of 6-(2,5-dichlorothiophen-3-yl)-3-methyl-4,5,6,7-tetrahydroindazol-4-one (0.211 g) and 1-amino-3-hydroxyguanidine hydrochloride (102 mg) were added ethanol (4 ml) and concentrated hydrochloric acid (0.1 ml), and the mixture was stirred at 90° C. for 4 hours. Under reduced pressure, the solvent was evaporated, and to the residue was ethanol (2 ml). Precipitated crystals were filtered, washed with ethanol and dried to give 6-(2,5-dichlorothiophen-3-yl)-4-(1-hydroxyguanidin-3-yl)imino-3-methyl-4,5,6,7-tetrahydroindazole hydrochloride (Compound 128) (0.225 g) as pale yellow crystals.

Aufarbeitung

  1. customUnder reduced pressure, the solvent was evaporated
  2. customPrecipitated crystals
  3. filtrationwere filtered
  4. washwashed with ethanol
  5. customdried

Quellen und Nachweise

ORD-Eintrag
ord-e3e2d3144d6a4be79ca470a1404fe6e8
Quelldatensatz
uspto-grants-2002_02
Patentnummer
US06350749B1

Notizen zur Reaktion

Wird geladen…