Hydrochloric Acid → HCID 178430926, Verbindung

HRID 1700674Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1700674
[Cl:1][C:2]1[S:3][C:4]([Cl:19])=[CH:5][C:6]=1[CH:7]1[CH2:16][C:15]2[N:14]=[N:13][CH:12]=[C:11]([CH3:17])[C:10]=2[C:9](=O)[CH2:8]1.[C:20]([NH:23][NH2:24])([NH2:22])=[NH:21].Cl.Cl>C(O)C>[ClH:1].[Cl:1][C:2]1[S:3][C:4]([Cl:19])=[CH:5][C:6]=1[CH:7]1[CH2:16][C:15]2[N:14]=[N:13][CH:12]=[C:11]([CH3:17])[C:10]=2[C:9](=[N:24][NH:23][C:20]([NH2:22])=[NH:21])[CH2:8]1

Komponenten

5

Edukt 3

HCID 313Hydrochloric AcidHCID 183174407-(2,5-Dichlorothiophen-3-yl)-4-methyl-5,6,7,8-tetrahydrocinnolin-5-oneHCID 178418668HCID 178418668, Verbindung

Produkt 1

HCID 178430926HCID 178430926, VerbindungAusbeute 190,1 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

To a mixture of 7-(2,5-dichlorothiophen-3-yl)-4-methyl-5,6,7,8-tetrahydrocinnolin-5-one (0.203 g) and aminoguanidine hydrochloride (80 mg) were added ethanol (6 ml) and concentrated hydrochloric acid (0.1 ml), and the mixture was refluxed for 1.5 hours and cooled. Precipitated crystals were filtered, washed with ethanol and dried to give 7-(2,5-dichlorothiophen-3-yl)-5-guanidinoimino-4-methyl-5,6,7,8-tetrahydrocinnoline hydrochloride (Compound 131) (0.25 g) as crystals.

Aufarbeitung

  1. temperaturethe mixture was refluxed for 1.5 hours
  2. temperaturecooled
  3. customPrecipitated crystals
  4. filtrationwere filtered
  5. washwashed with ethanol
  6. customdried

Quellen und Nachweise

ORD-Eintrag
ord-3bf440d775a045339eaa2adb1ab56f47
Quelldatensatz
uspto-grants-2002_02
Patentnummer
US06350749B1

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