Ammonium Acetate → 1-Amino-5-(2-fluoro-5-methylphenyl)cyclohexen-3-one

HRID 1700696Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1700696
[F:1][C:2]1[CH:7]=[CH:6][C:5]([CH3:8])=[CH:4][C:3]=1[CH:9]1[CH2:14][C:13](=O)[CH2:12][C:11](=[O:16])[CH2:10]1.C([O-])(=O)C.[NH4+:21]>C(O)C>[NH2:21][C:13]1[CH2:14][CH:9]([C:3]2[CH:4]=[C:5]([CH3:8])[CH:6]=[CH:7][C:2]=2[F:1])[CH2:10][C:11](=[O:16])[CH:12]=1

Komponenten

4

Edukt 2

HCID 517165Ammonium AcetateHCID 183174315-(2-Fluoro-5-methylphenyl)cyclohexane-1,3-dione

Produkt 1

HCID 183176231-Amino-5-(2-fluoro-5-methylphenyl)cyclohexen-3-oneAusbeute 87,1 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

A solution of 5-(2-fluoro-5-methylphenyl)cyclohexane-1,3-dione (1.5 g) and ammonium acetate (1.6 g) in ethanol (23 ml) was refluxed for 20 hours. Under reduced pressure, the solvent was evaporated, and precipitated crystals were washed with water and toluene, and dried to give 1-amino-5-(2-fluoro-5-methylphenyl)cyclohexen-3-one (1.3 g).

Aufarbeitung

  1. customUnder reduced pressure, the solvent was evaporated
  2. customprecipitated crystals
  3. washwere washed with water and toluene
  4. customdried

Quellen und Nachweise

ORD-Eintrag
ord-15bf297343ad43148504d34913f2ae9b
Quelldatensatz
uspto-grants-2002_02
Patentnummer
US06350749B1

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