Hydrochloric Acid → HCID 178430929, Verbindung

HRID 1700743Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1700743
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[CH:8]1[CH2:17][C:16]2[N:15]=[N:14][CH:13]=[C:12]([CH3:18])[C:11]=2[C:10](=O)[CH2:9]1.Cl.[NH2:21][NH:22][C:23]([NH:25][OH:26])=[NH:24].Cl>C(O)C>[ClH:1].[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[CH:8]1[CH2:17][C:16]2[N:15]=[N:14][CH:13]=[C:12]([CH3:18])[C:11]=2[C:10](=[N:21][NH:22][C:23](=[NH:24])[NH:25][OH:26])[CH2:9]1

Komponenten

5

Edukt 3

HCID 313Hydrochloric AcidHCID 110439264-Methyl-7-(2-chlorophenyl)-5,6,7,8-tetrahydrocinnolin-5-oneHCID 178479533HCID 178479533, Verbindung

Produkt 1

HCID 178430929HCID 178430929, VerbindungAusbeute 155,8 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Reaktionsbedingungen

Temperatur
90 °C

Versuchsvorschrift

To a mixture of 7-(2-chlorophenyl)-4-methyl-5,6,7,8-tetrahydrocinnolin-5-one (101 mg) and 1-amino-3-hydroxyguanidine hydrochloride (48 mg) were added ethanol (2 ml) and concentrated hydrochloric acid (0.05 ml), and the mixture was stirred at 90° C. for 1.5 hours. The reaction solution was concentrated under reduced pressure, and the residue was washed with ethanol and dried to give 7-(2-chlorophenyl)-5-(1-hydroxyguanidin-3-yl)imino-4-methyl-5,6,7,8-tetrahydrocinnoline hydrochloride (Compound 156) (110 mg) as gray white crystals.

Aufarbeitung

  1. concentrationThe reaction solution was concentrated under reduced pressure
  2. washthe residue was washed with ethanol
  3. customdried

Quellen und Nachweise

ORD-Eintrag
ord-74945a8e986c4309b9c1fccf668ebf59
Quelldatensatz
uspto-grants-2002_02
Patentnummer
US06350749B1

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