Hydrochloric Acid → HCID 178428728, Verbindung

HRID 1700744Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1700744
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[CH:8]1[CH2:17][C:16]2[N+:15]([O-:18])=[CH:14][CH:13]=[C:12]([CH3:19])[C:11]=2[C:10](=O)[CH2:9]1.[C:21]([NH:24][NH2:25])([NH2:23])=[NH:22].Cl.Cl>C(O)C>[ClH:1].[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[CH:8]1[CH2:17][C:16]2[N+:15]([O-:18])=[CH:14][CH:13]=[C:12]([CH3:19])[C:11]=2[C:10](=[N:25][NH:24][C:21]([NH2:23])=[NH:22])[CH2:9]1

Komponenten

5

Edukt 3

HCID 313Hydrochloric AcidHCID 183177547-(2-Chlorophenyl)-4-methyl-5,6,7,8-tetrahydroquinolin-5-one-1-oxideHCID 178418668HCID 178418668, Verbindung

Produkt 1

HCID 178428728HCID 178428728, VerbindungAusbeute 144,8 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

To a mixture of 7-(2-chlorophenyl)-4-methyl-5,6,7,8-tetrahydroquinolin-5-one-1-oxide (0.23 g) and aminoguanidine hydrochloride (100 mg) were added ethanol (6 ml) and concentrated hydrochloric acid (0.1 ml), and the mixture was refluxed for 3 hours. The reaction solution was cooled to room temperature, and the resulting crystals were filtered and dried to give 7-(2-chlorophenyl)-5-guanidinoimino-4-methyl-5,6,7,8-tetrahydroquinoline-1-oxide hydrochloride (Compound 157) (220 mg) as colorless crystals.

Aufarbeitung

  1. temperaturethe mixture was refluxed for 3 hours
  2. filtrationthe resulting crystals were filtered
  3. customdried

Quellen und Nachweise

ORD-Eintrag
ord-3e9fd6e8b1c64ba5953350fc5106dee4
Quelldatensatz
uspto-grants-2002_02
Patentnummer
US06350749B1

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