Hydrochloric Acid → HCID 178428729, Verbindung

HRID 1700745Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1700745
[Cl:1][C:2]1[S:3][C:4]([Cl:20])=[CH:5][C:6]=1[CH:7]1[CH2:16][C:15]2[N+:14]([O-:17])=[CH:13][CH:12]=[C:11]([CH3:18])[C:10]=2[C:9](=O)[CH2:8]1.[C:21]([NH:24][NH2:25])([NH2:23])=[NH:22].Cl.Cl>C(O)C>[ClH:1].[Cl:1][C:2]1[S:3][C:4]([Cl:20])=[CH:5][C:6]=1[CH:7]1[CH2:16][C:15]2[N+:14]([O-:17])=[CH:13][CH:12]=[C:11]([CH3:18])[C:10]=2[C:9](=[N:25][NH:24][C:21]([NH2:23])=[NH:22])[CH2:8]1

Komponenten

5

Edukt 3

HCID 313Hydrochloric AcidHCID 183177197-(2,5-Dichlorothiophen-3-yl)-4-methyl-5,6,7,8-tetrahydroquinolin-5-one-1-oxideHCID 178418668HCID 178418668, Verbindung

Produkt 1

HCID 178428729HCID 178428729, VerbindungAusbeute 175,8 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Reaktionsbedingungen

Temperatur
105 °C

Versuchsvorschrift

To a mixture of 7-(2,5-dichlorothiophen-3-yl)-4-methyl-5,6,7,8-tetrahydroquinolin-5-one-1-oxide (426 mg) and aminoguanidine hydrochloride (159 mg) were added ethanol (8 ml) and concentrated hydrochloric acid (0.15 ml), and the mixture was stirred at 105° C. for 2 hours. The reaction solution was cooled to room temperature, and the resulting crystals were filtered and dried to give 7-(2,5-dichlorothiophen-3-yl)-5-guanidinoimino-4-methyl-5,6,7,8-tetrahydroquinoline-1-oxide hydrochloride (Compound 158) (480 mg) as colorless crystals.

Aufarbeitung

  1. temperatureThe reaction solution was cooled to room temperature
  2. filtrationthe resulting crystals were filtered
  3. customdried

Quellen und Nachweise

ORD-Eintrag
ord-8bbe49a518024e0193596b8cff5521bc
Quelldatensatz
uspto-grants-2002_02
Patentnummer
US06350749B1

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