4,5,6,7-Tetrahydro-1-benzothiophen-4-amine → N-(4,5,6,7-Tetrahydro-1-benzothiophen-4-yl)urea
Reaktionsgleichung
[S:1]1[CH:5]=[CH:4][C:3]2[CH:6]([NH2:10])[CH2:7][CH2:8][CH2:9][C:2]1=2.[C:11]([NH:19][C@H](C(O)=O)CCC(O)=O)(=[O:18])C1C=CC=CC=1>>[S:1]1[CH:5]=[CH:4][C:3]2[CH:6]([NH:10][C:11]([NH2:19])=[O:18])[CH2:7][CH2:8][CH2:9][C:2]1=2Komponenten
3
Versuchsvorschrift
Similarly, the salt of (+)-4,5,6,7-tetrahydrobenzo[b]thiophen-4-amine and (S)-(-)-N-benzoyl glutamic acid is treated in the above manner to afford (+)-4,5,6,7-tetrahydrobenzo[b]thien-4-ylurea, melting point 218° C. to 220° C.; [α]58925 +60°, [α]436 +149.8°, [α]365 +272.5°.
Quellen und Nachweise
- ORD-Eintrag
- ord-924c876c542b49f595d2de706a00ef5b
- Quelldatensatz
- uspto-grants-1980_03
- Patentnummer
- US04191830
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