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HRID 1701749Erstellt: 24. Oktober 2026

Thionyl Chloride → 2,3-Dichloro-5-(chloromethyl)pyridine

https://huagongshe.com/de/reaction/1701749

Reaktionsgleichung

Beteiligte Stoffe

RolleNameHCIDEinwaage
EduktThionyl ChlorideHCID 24386—
Edukt(5,6-Dichloropyridin-3-yl)methanolHCID 21882961—
Produkt2,3-Dichloro-5-(chloromethyl)pyridineHCID 10176536—

Reaktionsschritte

2,3-Dichloro-5-hydroxymethyl-pyridine is reacted in a known manner with thionyl chloride to give 5-chloromethyl-2,3-dichloro-pyridine and the latter is reacted with sodium cyanide, without additional purification (for example analogously to L. A. Carlson et al., Acta Pharm. Suecica 9, 411 (1972)). 5,6-Dichloro-pyridine-3-acetonitrile, thus obtained, melts at 72°-75° C. after recrystallisation from ether.

Herkunft & Nachweise

DOI10.6084/m9.figshare.5104873.v1
PatentnummerUS04195090
Quelldatensatzuspto-grants-1980_03
ORD IDord-094b3d4c72d5409c841d749bec1227c2
Quellennotizuspto-grants-1980_03