Benzylamine → HCID 57857600, Verbindung

HRID 17022Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 17022
Cl[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[CH:8]1[CH2:10][CH:9]1[CH:11]1[CH2:13][CH2:12]1.[CH2:14]([NH2:21])[C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1.C([O-])(C)(C)C.[Na+].C(OCC)(=O)C>C(COC)OC>[CH2:14]([NH:21][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[CH:8]1[CH2:10][CH:9]1[CH:11]1[CH2:13][CH2:12]1)[C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1

Komponenten

6

Edukt 4

HCID 7504BenzylamineHCID 8857Ethyl AcetateHCID 23676156Sodium t-butoxideHCID 673713862-(2-Chlorophenyl)bicyclopropyl

Produkt 1

HCID 57857600HCID 57857600, VerbindungAusbeute 87,1 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 80711,2-DimethoxyethaneLösungsmittel

Versuchsvorschrift

3 g of 2-(2-chlorophenyl)bicyclopropyl (15.6 mmol, trans/cis ratio of about 2:1), 2.5 g of benzylamine (23.4 mmol), 2.4 g of sodium tert-butanolate (25 mmol), 35 mg of Pd(II) acetate (0.16 mmol) and 60 mg of R(−)-di-tert-butyl-[1-[(S)-2-(dicyclohexylphosphanyl)-ferrocenyl]ethyl]phosphine (0.11 mmol) are dissolved in 30 ml of dimethoxyethane. The reaction mixture is heated to the reflux temperature of the solvent and is stirred for 24 hours. After cooling, ethyl acetate is added and the organic phase is washed with water. The solvent is removed using a water jet vacuum and the residue is dried. The product is purified by column chromatography on silica gel (eluant:ethyl acetate/hexane 1:15). 3.58 g of benzyl(2-bicyclopropyl-2-yl-phenyl)amine (87% of theory) are obtained in the form of a brown oil (trans/cis ratio of about 2:1).

Aufarbeitung

  1. temperatureThe reaction mixture is heated to the reflux temperature of the solvent
  2. temperatureAfter cooling
  3. washthe organic phase is washed with water
  4. customThe solvent is removed
  5. customthe residue is dried
  6. customThe product is purified by column chromatography on silica gel (eluant:ethyl acetate/hexane 1:15)

Quellen und Nachweise

ORD-Eintrag
ord-02745a7007724ba18c99b68f891541fd
Quelldatensatz
uspto-grants-2010_06
Patentnummer
US07737301B2

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