Chloroform → 3-[4-(Hexadecylamino)cinnamoyl]-4-carboethoxy thiazolidine

HRID 1702701Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1702701
Cl.[CH2:2]([NH:18][C:19]1[CH:29]=[CH:28][C:22]([CH:23]=[CH:24][C:25](Cl)=[O:26])=[CH:21][CH:20]=1)[CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH3:17].[S:30]1[CH2:34][CH:33]([C:35]([O:37][CH2:38][CH3:39])=[O:36])[NH:32][CH2:31]1.C(Cl)(Cl)Cl.C(N(CC)CC)C>C(Cl)Cl>[CH2:2]([NH:18][C:19]1[CH:29]=[CH:28][C:22]([CH:23]=[CH:24][C:25]([N:32]2[CH:33]([C:35]([O:37][CH2:38][CH3:39])=[O:36])[CH2:34][S:30][CH2:31]2)=[O:26])=[CH:21][CH:20]=1)[CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH3:17]

Komponenten

6

Edukt 4

HCID 6212ChloroformHCID 8471TriethylamineHCID 103574Ethyl thiazolidine-4-carboxylateHCID 73682495HCID 73682495, Verbindung

Produkt 1

HCID 544239453-[4-(Hexadecylamino)cinnamoyl]-4-carboethoxy thiazolidine

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

One-tenth mole of 4-(hexadecylamino)cinnamoyl chloride hydrochloride in methylene chloride is added to a solution of 0.1 mole of ethyl thiazolidine-4-carboxylate in chloroform containing two equivalents of triethylamine. After 5 hours at 20° C. the solution is filtered and evaporated to a white solid which is recrystallized from acetonitrile.

Aufarbeitung

  1. filtrationAfter 5 hours at 20° C. the solution is filtered
  2. customevaporated to a white solid which
  3. customis recrystallized from acetonitrile

Quellen und Nachweise

ORD-Eintrag
ord-db49e442d3e84cef8558d12d05b7c08f
Quelldatensatz
uspto-grants-1982_09
Patentnummer
US04348399

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