Timonacic → 3-[4-(Hexadecylamino)cinnamoyl]-4-carboxythiazolidine

HRID 1702702

Reaktionsgleichung

Reaktionsgleichung von HRID 1702702
[CH2:1]([NH:17][C:18]1[CH:37]=[CH:36][C:21]([CH:22]=[CH:23][C:24]([N:26]2[CH:30]([C:31]([O:33]CC)=[O:32])[CH2:29][S:28][CH2:27]2)=[O:25])=[CH:20][CH:19]=1)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH3:16].S1CC(C(O)=O)NC1>C(=O)(O)[O-].[Na+].CC(C)=O>[CH2:1]([NH:17][C:18]1[CH:19]=[CH:20][C:21]([CH:22]=[CH:23][C:24]([N:26]2[CH:30]([C:31]([OH:33])=[O:32])[CH2:29][S:28][CH2:27]2)=[O:25])=[CH:36][CH:37]=1)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH3:16]

Komponenten

4

Edukt 2

HCID 9934TimonacicHCID 544239453-[4-(Hexadecylamino)cinnamoyl]-4-carboethoxy thiazolidine

Produkt 1

HCID 538485433-[4-(Hexadecylamino)cinnamoyl]-4-carboxythiazolidine

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 86737261Acetone sodium bicarbonateLösungsmittel

Versuchsvorschrift

By means of the alkaline hydrolysis method of Example 54, the ethyl ester of Example 51 is converted to the subject carboxylic acid. This acid is also prepared using the procedure of Example 51 except that the acylation of the thiazolidine-4-carboxylic acid is carried out in aqueous acetone sodium bicarbonate solution.

Aufarbeitung

  1. customBy means of the alkaline hydrolysis method of Example 54
  2. customThis acid is also prepared

Quellen und Nachweise

ORD-Eintrag
ord-3276e6d51ce04e0f984c16c2e5bea113
Quelldatensatz
uspto-grants-1982_09
Patentnummer
US04348399

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